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23 Jun
Women Still Underrepresented in Many Clinical Trials

Women Still Underrepresented in Many Clinical Trials

To ensure that all kinds of patients get drugs and devices that are safe and effective for them, they need to be represented in clinical trials, but a new study shows that

15 Jun
Cancer Clinical Trials Make Comeback After Pandemic Slowdown

Cancer Clinical Trials Make Comeback After Pandemic Slowdown

Cancer clinical trials in the United States appear to be rebounding after a significant slowdown during the pandemic, researchers say.

For the study, the investigators analyzed da...

06 Jun
New Weight-Loss Drug Looks Good in Trial

New Weight-Loss Drug Looks Good in Trial

A newly approved drug for type 2 diabetes may be a game-changer for treating obesity, too.

Given as a shot once a week, tirzepatide works on two naturally occurring hormones that help tell the brain that you are full. It may be as effective as weight-loss surgery.

...

06 Jun
In Small Study, New Treatment Brings Remission of Rectal Cancer in All Patients

In Small Study, New Treatment Brings Remission of Rectal Cancer in All Patients

A small study delivers startling results on the power of a new immunotherapy treatment against rectal cancer: The drug triggered remission in all the patients who got it.

...

16 May
Immunotherapy Drug Can Lower Recurrence When Bladder Cancer Spreads

Immunotherapy Drug Can Lower Recurrence When Bladder Cancer Spreads

Immunotherapy with nivolumab (Opdivo) after surgery for metastatic bladder cancer significantly reduces the odds for the tumor's return, a new clinical trial finds.

Among 700 patients with

22 Apr
Tongue Stimulator Shows Promise as Sleep Apnea Treatment in Kids With Down Syndrome

Tongue Stimulator Shows Promise as Sleep Apnea Treatment in Kids With Down Syndrome

Children with Down syndrome are more likely than other kids to have sleep apnea, and existing treatments often fail to work.

Now, an implanted device that stimulates tongue nerves shows promise in reducing their sleep disruptions, a new study finds.

A device calle...

13 Apr
Black Patients Less Likely to Get Into Pancreatic Cancer Clinical Trials

Black Patients Less Likely to Get Into Pancreatic Cancer Clinical Trials

Black Americans are far less likely to be included in clinical trials of pancreatic cancer drugs than white Americans, and eligibility criteria are a significant factor in that gap, according to a new study.

"The standard of care in cancer treatment is informed by studie...

29 Mar
Saving the 'Butterfly Children:' Gene Therapy Helps Heal Deadly Blistering Condition

Saving the 'Butterfly Children:' Gene Therapy Helps Heal Deadly Blistering Condition

An experimental cream-based gene therapy may soon become the first U.S. government-approved means for treating a rare and devastating skin disease that produces "butterfly children."

Patients with recessive dystrophic

07 Feb
Ketamine May Be Emergency Deterrent for People at Risk of Suicide

Ketamine May Be Emergency Deterrent for People at Risk of Suicide

A new clinical trial strengthens the case that ketamine -- once famous as a club drug -- can rapidly ease suicidal thoughts.

Researchers found that among 156 adults hospitalized for severe suicidal thoughts, those given two doses of ketamine often saw those disturbing id...

03 Feb
A Better Clot-Buster Drug When Strokes Attack?

A Better Clot-Buster Drug When Strokes Attack?

A newer type of "clot-busting" medication might be safer than the one long used for treating strokes, a preliminary study hints.

Researchers found that among nearly 7,900 stroke sufferers, those treated with the drug -- called tenecteplase -- were less likely to suffer l...

02 Feb
Getting Active Soon After Concussion May Aid Kids' Recovery

Getting Active Soon After Concussion May Aid Kids' Recovery

A return to non-contact physical activity three days after a concussion is safe and possibly even beneficial for kids, a Canadian clinical trial finds.

"Gone are the days of resting in a dark room," said study co-author Andrée-Anne Ledoux, a scientist at the Children's ...

27 Jan
Newer Rheumatoid Arthritis Drug Might Raise Heart, Cancer Risks

Newer Rheumatoid Arthritis Drug Might Raise Heart, Cancer Risks

Finding the right medication for rheumatoid arthritis isn't easy, and a newer pill against the disease carries higher risks of heart attack, stroke and cancer than older RA drugs, a new clinical trial confirms.

The study was mandated by the U.S. Food and Drug Administrat...

26 Jan
Saline IV Drip Just as Good as Pricier Options in Hospital ICUs: Study

Saline IV Drip Just as Good as Pricier Options in Hospital ICUs: Study

Saline intravenous (IV) fluids are as effective as more costly solutions in treating intensive care patients and keeping them alive, Australian researchers report.

"Just about every patient admitted to the intensive care unit (ICU) will receive intravenous fluids for res...

21 Jan
Exposing Kids to Safe Levels of Peanut When Young Might Prevent Allergy

Exposing Kids to Safe Levels of Peanut When Young Might Prevent Allergy

Some kids might be able to get over their peanut allergy if they start immunotherapy while they're still toddlers, a major new clinical trial reports.

In the trial, a group of 1- to 3-year-olds with severe

13 Jan
Immune-Based Drug Fights Advanced Endometrial Cancer: Study

Immune-Based Drug Fights Advanced Endometrial Cancer: Study

A drug used to treat several types of cancer is also an effective treatment for aggressive forms of endometrial cancer, the second most common cancer in women worldwide, a new clinical trial shows. The endometrium is the inner lining of the uterus.

"These findings sugges...

10 Jan
Drug Combo Boosts Outcomes for Advanced Melanoma

Drug Combo Boosts Outcomes for Advanced Melanoma

For people newly diagnosed with advanced melanoma, a combination of two immunotherapy drugs can double the amount of time their cancer remains progression-free, a clinical trial has found.

The treatment combines two drugs known as immune checkpoint inhibitors. One, calle...

06 Jan
Drug Might Help Ease 'Sensory Demands' of Autism

Drug Might Help Ease 'Sensory Demands' of Autism

A medication that acts on certain brain receptors can temporarily ease visual-processing problems in some adults with autism, a small study has found.

Researchers said it's far too early to know whether the drug, arbaclofen, could prove useful in managing those visual is...

03 Jan
Once-a-Day HIV Pill Works Well for Kids

Once-a-Day HIV Pill Works Well for Kids

An international trial found that a once-a-day antiretroviral medication for kids with HIV is not only cheap and easy to take, but also better at suppressing HIV than standard treatments.

"Our findings provide strong evidence for the global rollout of dolutegravir for ch...

27 Dec
Could a High-Fiber Diet Help Boost Cancer Survival?

Could a High-Fiber Diet Help Boost Cancer Survival?

People undergoing immune-boosting therapy for advanced melanoma may respond better if they eat a high-fiber diet, a new study hints.

Researchers said much more study is needed, but their initial findings -- in both melanoma patients and lab mice -- suggest that

22 Dec
Fish Oil Has No Effect on Depression, Study Finds

Fish Oil Has No Effect on Depression, Study Finds

They may have other proven health benefits, but new research shows that fish oil supplements don't prevent depression or improve mood.

Some experts recommend omega-3 fish oil sup...

17 Dec
Pfizer Vaccine Disappoints in Kids Ages 2 to 5

Pfizer Vaccine Disappoints in Kids Ages 2 to 5

Two doses of a pediatric Pfizer-BioNTech COVID-19 vaccine failed to spur an adequate immune response in children aged 2 to 5, the companies announced Friday.

That's a setback for parents hoping to get their youngest children immunized against the new coronavirus as soon ...

15 Dec
Drug Combo May Fight a Tough Form of Breast Cancer

Drug Combo May Fight a Tough Form of Breast Cancer

An experimental drug, added to chemotherapy, may benefit women with an aggressive form of breast cancer, suggests an early study offering much-needed good news.

The study involved women with "triple-negative" breast cancer, which accounts for about 15% to 20% of breast c...

13 Dec
Could Gene Therapy Help Cure Sickle Cell Disease?

Could Gene Therapy Help Cure Sickle Cell Disease?

A gene therapy that could provide a permanent cure for sickle cell disease continues to show success through a third wave of patients, researchers report.

The therapy, LentiGlobin, restored normal blood function in 35 sickle cell patients who had the one-time procedure, ...

10 Dec
New Treatment Greatly Boosts Survival for Kids With Aggressive Brain Cancer

New Treatment Greatly Boosts Survival for Kids With Aggressive Brain Cancer

Children with the rare cancer neuroblastoma often succumb to the disease despite aggressive treatment. But researchers have found that adding an experimental antibody to that treatment, right off the bat, may improve their outlook.

Of 64 children treated with the antibod...

09 Dec
New Asthma Drug Helps Kids, But Price Tag Is High

New Asthma Drug Helps Kids, But Price Tag Is High

Children with hard-to-control asthma may get relief from adding an injectable antibody drug to their standard treatment, a clinical trial has found.

The drug, called dupilumab (Dupixent), has been available for several years to treat stubborn asthma in adults and teenage...

30 Nov
Clinical Trials Are Becoming More Diverse, But There's Still Work To Do

Clinical Trials Are Becoming More Diverse, But There's Still Work To Do

U.S. cancer clinical trial participants have become more diverse in makeup, but certain groups remain underrepresented, a new study finds.

It's important to have a wide range of participants in clinical trials, to find out if treatments are safe and effective for people ...

23 Nov
Drug Long Used for Alcoholism Might Fight Severe COVID-19

Drug Long Used for Alcoholism Might Fight Severe COVID-19

A widely available drug used to treat alcoholism has potential as a COVID-19 treatment, researchers say.

The investigators found that people taking disulfiram (Antabuse) for alcoholism had a lower risk of infection with SARS-CoV-2 and were less likely to die from COVID-1...

22 Nov
Wearable Vibration Device May Ease Parkinson's Tremor

Wearable Vibration Device May Ease Parkinson's Tremor

Physiotherapist David Putrino was working on a vibrating glove to help deaf people experience live music when a friend mentioned that the same technology might stop tremors in people with Parkinson's disease.

Putrino, director of rehabilitation innovation for Mount Sinai...

18 Nov
Neurologists' Group Issues Guidance to Families on Controversial Alzheimer's Drug

Neurologists' Group Issues Guidance to Families on Controversial Alzheimer's Drug

Neurologists must make sure Alzheimer's patients and their families understand that the controversial drug aducanumab does not restore mental function, the American Academy of Neurology (AAN) said in new position statement that includes ethical guidelines.

"Aducanumab is...

17 Nov
Trial Begins of Nasal Vaccine for Alzheimer's Disease

Trial Begins of Nasal Vaccine for Alzheimer's Disease

The first human clinical trial of a nasal vaccine to slow the progression of Alzheimer's disease is set to begin after nearly 20 years of research.

This is a "remarkable milestone," according to Dr. Howard Weiner, co-director of the Ann Romney Center for Neurologic Disea...

16 Nov
Stem Cell Therapy Boosts Outcomes for Some Heart Failure Patients

Stem Cell Therapy Boosts Outcomes for Some Heart Failure Patients

Heart failure patients who fit a specific profile can benefit from injection of stem cells delivered directly into their heart muscle, a new study finds.

Patients with mild or moderate heart failure who have high levels of inflammation responded well to the stem cell inj...

12 Nov
More Evidence That COVID Vaccines Are Safe for Cancer Patients

More Evidence That COVID Vaccines Are Safe for Cancer Patients

COVID-19 vaccines are safe and effective for most cancer patients, a new study confirms.

Cancer patients have an increased risk of severe illness and death from COVID because their immune systems have been weakened by their disease or treatments.

"We pursued this s...

10 Nov
Placebo Effect Plays Big Role in Antidepressant's Impact on Anxiety: Study

Placebo Effect Plays Big Role in Antidepressant's Impact on Anxiety: Study

Illustrating the power of the mind to heal itself, new research suggests that the placebo effect could help drive antidepressants' effects against anxiety disorders.

The placebo effect refers to an increase in the success of a treatment when a patient expects a benefit.<...

02 Nov
We've Been Here Before: How Polio Vaccine Rollout Saved Millions of Young Lives

We've Been Here Before: How Polio Vaccine Rollout Saved Millions of Young Lives

An infection that can disable and kill stalks the land, but a brand-new vaccine offers hope that almost everyone, kids included, can evade it. After scientific testing, a nationwide rollout of the vaccine begins.

Sound familiar?

As the U.S. government gears up to ...

29 Oct
How Two People With HIV Suppressed Virus After Stopping Treatment

How Two People With HIV Suppressed Virus After Stopping Treatment

There are two ways that HIV patients' bodies can keep the virus under control after they stop antiretroviral therapy, a new study shows.

The findings could point to ways to help people with HIV keep the virus in remission without having to keep taking medications that ca...

27 Oct
Shorter Course of Post-Op Radiation May Work Well for Prostate Cancer Patients

Shorter Course of Post-Op Radiation May Work Well for Prostate Cancer Patients

After prostate cancer surgery, men can safely undergo fewer radiation treatments at higher doses, a new clinical trial shows.

Researchers found that the shorter regimen -- given over five weeks, instead of seven -- did not raise patients' odds of lasting side effects.

26 Oct
Targeted High-Dose Radiation Helps Fight Advanced Lung Cancer

Targeted High-Dose Radiation Helps Fight Advanced Lung Cancer

High-dose radiation therapy may stall tumor growth in patients with advanced lung cancer who are not fully responding to drug therapies, a preliminary study suggests.

The study involved patients whose lung cancer was considered "oligoprogressive." That means the cancer h...

25 Oct
Moderna Says Its COVID Vaccine Works Well in Children Aged 6 to 11

Moderna Says Its COVID Vaccine Works Well in Children Aged 6 to 11

Moderna announced Monday that its COVID-19 vaccine safely triggers a strong immune response in children aged 6 to 11.

21 Oct
Pfizer Vaccine Booster Restores Nearly Full Protection, Company Says

Pfizer Vaccine Booster Restores Nearly Full Protection, Company Says

The Pfizer-BioNTech vaccine booster restored close to full protection against COVID-19 in a late-stage trial involving 10,000 people, the company announced Thursday.

They said the booster was 95.6% effective and that they plan to submit the latest data to the U.S. Food a...

19 Oct
Still Too Few Women in Stroke Treatment Clinical Trials

Still Too Few Women in Stroke Treatment Clinical Trials

Men still outnumber women in stroke therapy clinical trials, which means women may end up receiving less effective treatment, researchers say.

For the new study, investigators analyzed 281 stroke trials that included at least 100 patients each and were conducted between ...

13 Oct
Another Study Suggests Too Much Fish Oil Could Trigger A-Fib

Another Study Suggests Too Much Fish Oil Could Trigger A-Fib

A new study confirms that fish oil supplements may raise the risk of a common heart-rhythm disorder -- particularly when doses top 1 gram per day.

At issue are medications and supplements containing omega-3 fatty acids, which are naturally found in fish oil.

Fish i...

12 Oct
Anti-Nausea Drug May Boost Survival for Some Cancer Patients

Anti-Nausea Drug May Boost Survival for Some Cancer Patients

Patients who undergo surgery for certain types of cancer may have better short-term survival if they receive a particular anti-nausea drug, a preliminary study suggests.

Among more than 74,000 patients who had cancer surgery, researchers found that those who received the...

29 Sep
New Hope for IBD Patients

New Hope for IBD Patients

A drug previously approved for multiple sclerosis also can treat inflammatory bowel disease in some patients, a new clinical trial reports.

The medication, ozanimod (Zeposia), proved effective in helping patients with ulcerative colitis, sending many into full remission,...

24 Sep
Trials Show COVID Vaccines Well Worth It for Cancer Patients

Trials Show COVID Vaccines Well Worth It for Cancer Patients

If you have cancer and you think coronavirus vaccines may do you little good, don't let your hesitation stop you from getting the shots: A pair of clinical trials finds that patients' immune systems ramped up after vaccination.

The findings were presented this week durin...

20 Sep
New Drug Combo Boosts Survival Against Aggressive Form of Breast Cancer

New Drug Combo Boosts Survival Against Aggressive Form of Breast Cancer

New research offers good news for women with an aggressive HER2-positive breast cancer.

A targeted therapy, trastuzumab deruxtecan (T-DXd), sold as Enhertu, triples the length of time that the cancer remains in check when compared with the current gold standard, trastuzu...

17 Sep
Trial Into Antioxidant for Parkinson's Disease Yields Disappointing Results

Trial Into Antioxidant for Parkinson's Disease Yields Disappointing Results

FRIDAY, Sept. 17, 2021 (HealthDay News) -- Researchers hoped to show that the natural antioxidant urate could delay Parkinson's disease progression, but a study completed at Massachusetts General Hospital dashed those expectations.

The trial enrolled nearly 300 individ...

14 Sep
Ebola Vaccine Effective in African Clinical Trial

Ebola Vaccine Effective in African Clinical Trial

An experimental Ebola vaccine appeared effective in children and adults in a clinical trial.

Two doses of Johnson & Johnson's Ebola vaccine appear safe, well tolerated and produce a strong immune response in people over the age of 1,

13 Sep
Data Doesn't Support Need for COVID-19 Vaccine Boosters: Experts

Data Doesn't Support Need for COVID-19 Vaccine Boosters: Experts

COVID-19 vaccine booster shots might not be needed for most people, according to a large international review.

The review -- conducted by a team that included scientists from the World Health Organization and the U.S. Food and Drug Administration -- concluded that curre...

27 Aug
Could a Long-Used Cholesterol Drug Fight Severe COVID-19?

Could a Long-Used Cholesterol Drug Fight Severe COVID-19?

A drug that lowers cholesterol might help save hospitalized patients with COVID-19, a new, small Israeli study suggests.

Researchers at Hebrew University of Jerusalem noted that COVID causes a big buildup of cholesterol, which results in inflammation in cells.

In l...

26 Aug
Could Electrode 'Pulses' Cut Back, Leg Pain Without Drugs?

Could Electrode 'Pulses' Cut Back, Leg Pain Without Drugs?

A new approach to spinal cord stimulation may drastically reduce chronic back pain, a small pilot study suggests.

The study, of 20 patients with stubborn low back pain, tested the effects of implanting electrodes near the spinal cord to stimulate it with "ultra-low" freq...